Inflammation: Mouse Models

ONCOLOGY

	Overview
	Therapeutic Program
	Gene Signatures & Assays
	Cancer Cell Lines

INFLAMMATION

	Overview
	Mouse Models
	Inflammation Cell Lines

Nuclea, in conjunction with Clark, is developing a mouse model of HPS, which exhibits striking abnormalities of lung type II cells. Type II cells and lamellar bodies of this mutant are greatly enlarged, and the lamellar bodies are engorged with surfactant. The air spaces of mutant lungs contain age-related elevations of inflammatory cells and foamy macrophages. In vivo measurement of lung hysteresivity demonstrated aberrant lung function in mutant mice. All these features are similar to the lung pathology described in HPS patients. Morphometry of mutant lungs indicates significant emphysema. These mutant mice provide a model to further investigate the lung pathology and therapy of HPS, and other types of inflammatory diseases.

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